An Imaging Gene by Environment Interaction (IG×E) Approach to Understanding Youth Antisocial Behavior
Title
An Imaging Gene by Environment Interaction (IG×E) Approach to Understanding Youth Antisocial Behavior
Author
Waller, Rebecca
Dotterer, Hailey L.
Hyde, Luke W.
Research Area
Special Areas of Interdisciplinary Study
Topic
Genetics, the Individual and Society
Abstract
An examination of the complex interplay of genes, environmental experience, and the brain is critical to understanding psychopathology, violence, and aggression. This essay reviews the gene–environment (G×E) interaction and imaging genetics literature relating to the development of youth antisocial behavior (AB). A model is proposed that bridges these approaches within an imaging gene×environment (IG×E) interaction framework. The potential application of an IG×E framework to youth AB is outlined and ongoing research challenges are discussed.